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A CHR Trial Investigation Outcomes of Exercise Training
PI: Jenny Adams
Funding Organization: NIH
IRG: GMA
Project Start: April 16, 2004
Project End: July 31, 2007
 
Primary Objective: To test the primary hypothesis that patients with LV systolic dysfunction and NYHA class II-IV symptoms who are given exercise training in addition to usual care will have a 20% lower rate of death and hospitalization over two years than patients who receive usual care alone.

Secondary Objectives: To test the hypothesis that the intervention to be studied will cause complications and thus will be associated with some short-term risk. To test the hypothesis that patients receiving the intervention will significantly improve exercise tolerance, as measured by peak VO2, heart rate at end of stage 2 and 6-minute walk distance versus patients in the usual care (control) arm. To test the hypothesis that exercise training will significantly improve the health-related quality of life patients in the intervention arm of the study versus the usual care group. To test the hypothesis that exercise training will be economically attractive (cost saving or a reasonable value for the money).